CSM

CYP2A (2A6)

CYP2B (2B4)

CYP2C (2C8)

CYP2D (2D6)

7

Absent

177NIICSIVF184(2.4)

172CAPCNVIC179(2.8)

180KAVSN184

8

193YKDKEFLS200

187RFDYKD192(2.2)

186RFDYKD191(2.2)

192GRRFEYDDP200

9

217GQLYEMFSSVM227

210SSFSSQVFELFS221(2.4)

211PWIQVCNNFP220(2.2)

225NAVPVLLHIPALAGK239

10

Absent

226HFPGTH231(2.0)

225CFPGTH230(1.8)

Absent

11

260DPNSP264

261PRDFIDVY268(1.6)

260PRDFIDC266(2.0)

Absent

The number of CYP sequences analyzed for each family is shown in parenthesis
The CYP sequences used from various species are presented earlier (22)
The colors of the residues in the motifs represent the rank order of sequence conservation as a function of relative entropy; red is the least conserved (>75%), black is intermediate (75-90%),
and blue represents the most conserved (>90%)
aThe rank is shown in parenthesis. The rank of CYP2A and CYP2D are ≤1.2
“Absent” in CYP2A and CYP2D represents lack of their respective CSM based on PCPMer motifs analysis
Residues and their numbers in the motifs for each CYP2 subfamilies are based on the specific CYP indicated in the first row
Table 3: Identification and analysis of PCPMer motifs of CYP2A (12), CYP2B (10), CYP2C (33), and CYP2D (25) enzymes in the E-H region.