CYPs

CSM 7

CSM 8

CSM 10

CSM 11

1A1

166EAEVLISTLQ175

183HFNPYRY189

224FGEVVGSG231

251FKDLNEKFYSF261

1A2

168EAKALISRLQ177

185HFDPYNQ190

226FVETASSQ232

253FKAFNQRFLWF263

2A6

177TVSNVIS183

190RFDYKD195

229HLPGPQ234

264PRDFIDS270

2A7

177TVSNVIS183

190RFDYED195

229HVPGPQ234

264PRDFIDS270

2A13

177CVSNVIC183

190RFEYAN195

229HVPGPH234

264PRDLIDS270

2B6

173ITANIIC180

187RFHYQD192

226YFPGAH231

261PKDLIDT267

2C8

172CAPCNVIC179

186RFDYKD191

225CFPGTH230

260PRDFMDC266

2C9

172CAPCNVIC179

186RFDYKD191

225YFPGTH230

260PQDFIDC266

2C18

172CAPCNVIC179

186RFDYKD191

225YLPGSH230

260ARDFIDC266

2C19

172CAPCNVIC179

186RFDFLD191

225YFPGTH230

268PRDFIDC274

2D6

180KAVSNVIA187

194RFEYDD199

232HIPALA237

217PRDLTEA223

2E1

174CAPYNVIA181

188HFDYND193

227YLPGSH232

262PRDLTDC268

3A4

189FGVNIDS195

212RFDFLD217

224IVFPFL229

258ESRLEDT264

3A5

189FGVNIDS195

212KFGFLD217

224ILFPFL229

258KSRLNDK264

3A7

189FGVSIDS195

212RFNPLD217

224KVFPFL229

258EGRLKET264

The CSM in all the CYPs is based on PCPMer motifs identified in the respective CYP1, CYP2, and CYP3 families (Table 2) The colors of the residues in the motifs represent the rank order of sequence conservation as a function of relative entropy; red is the least conserved (>75%), black is intermediate (75-90%), and blue represents the most conserved (>90%) The order of residues conservation was determined manually using the known CYP sequences from various species in the respective families; 1A, 2A, 2B, 2C, 2D, 2E, and 3A CSM 9 is not shown because it is not found in CYP1 and CYP3 families and is least conserved in CYP2 family
Table 4: Comparison and analysis of CSM 7, 8, 10, and 11 sequences in important drug metabolizing human CYP enzymes.