Number Gene Symbol Gene Title P-value Fold Change Sex Biased
1 SLC3A1 solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of
cystine, dibasic and neutral amino acid transport), member 1
7.27E-12 2.35 F
2 CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.28E-10 2.1 F
3 ACSL4 acyl-CoA synthetase long-chain family member 4 0.00266 2 F
4 CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 9.35E-08 1.83 F
5 GSTA1 glutathione S-transferase A1 0.000132 1.82 F
6 CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 5.25E-06 1.73 F
7 GSTA2 glutathione S-transferase A2 0.00266 1.69 F
8 UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 0.0002 1.59 M
9 SLC13A1 solute carrier family 13 (sodium/sulfate symporters), member 1 0.0166 1.57 M
10 ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.00003 1.53 F
11 CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.0147 1.49 F
12 SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.00288 1.48 F
13 CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 0.0212 1.46 F
14 GSTA5 glutathione S-transferase A5 0.00496 1.43 F
15 CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 0.0272 1.43 F
16 HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 1.03E-06 1.39 F
17 GLYAT glycine-N-acyltransferase 0.00223 1.38 F
18 SLC16A8 solute carrier family 16, member 8 (monocarboxylic acid transporter 3) 0.0419 1.35 F
19 FMO3 flavin containing monooxygenase 3 0.0025 1.34 F
20 ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 0.00801 1.34 M
21 CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.0265 1.33 F
22 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.0367 1.33 F
23 CYP2B7P1 cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1 0.034 1.32 F
24 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.0116 1.31 F
25 EPHX2 epoxide hydrolase 2, cytoplasmic 0.00129 1.3 F
26 CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 0.00074 1.3 F
27 SLCO1B1 solute carrier organic anion transporter family, member 1B1 0.0151 1.29 F
28 CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 0.00138 1.29 F
29 ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.0133 1.29 M
30 SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 8.32E-06 1.29 M
31 SLC16A14 solute carrier family 16, member 14 (monocarboxylic acid transporter 14) 0.0298 1.28 M
32 FMO1 flavin containing monooxygenase 1 4.37E-08 1.27 F
33 ALDH1B1 aldehyde dehydrogenase 1 family, member B1 0.0151 1.27 F
34 CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.00455 1.27 F
35 NR1I2 nuclear receptor subfamily 1, group I, member 2 0.00354 1.25 F
36 GNMT glycine N-methyltransferase 0.0424 1.25 F
37 UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 0.0344 1.25 F
38 UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 0.00407 1.24 F
39 SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.0103 1.24 F
40 ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.00812 1.23 F
41 SLC22A1 solute carrier family 22 (organic cation transporter), member 1 0.0125 1.22 F
42 AADAC arylacetamide deacetylase (esterase) 0.00517 1.22 F
43 BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) 0.0242 1.22 F
44 CES4 carboxylesterase 4 (monocyte/macrophage serine esterase 4) 0.0158 1.22 F
45 SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.000551 1.22 M
46 ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.0252 1.21 F
47 ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.00186 1.21 F
48 NNMT nicotinamide N-methyltransferase 0.000628 1.21 M
49 UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 0.0345 1.2 F
50 CBR1 carbonyl reductase 1 0.000228 1.2 F
51 ALDH5A1 aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) 0.00441 1.2 F
52 CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.000344 1.2 F
53 GPX2 glutathione peroxidase 2 (gastrointestinal) 0.000185 1.2 M
54 ORM2 orosomucoid 2 0.0023 1.2 M
55 HNMT histamine N-methyltransferase 0.00187 1.19 F
56 FMO5 flavin containing monooxygenase 5 0.034 1.19 F
57 MAOB monoamine oxidase B 0.0106 1.19 F
58 CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 0.00155 1.19 F
59 ORM1 orosomucoid 1 0.00164 1.19 M
60 CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.00038 1.18 F
61 SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.0355 1.18 F
62 SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.0116 1.18 F
63 ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 4.61E-06 1.17 F
64 SAT1 spermidine/spermine N1-acetyltransferase 1 0.00121 1.17 F
65 SLC16A9 solute carrier family 16, member 9 (monocarboxylic acid transporter 9) 0.0261 1.17 F
66 SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2 0.00207 1.17 M
67 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.000414 1.17 M
68 ACSL1 acyl-CoA synthetase long-chain family member 1 0.0122 1.16 F
69 CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.00892 1.16 F
70 CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 0.0123 1.16 F
71 GPX3 glutathione peroxidase 3 (plasma) 0.0000818 1.16 M
72 CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1) 0.018 1.15 F
73 SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 0.0323 1.15 M
74 SLC22A4 solute carrier family 22 (organic cation transporter), member 4 0.00243 1.14 M
75 ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 4.72E-06 1.13 M
76 SLC22A23 solute carrier family 22, member 23 0.0134 1.13 M
77 CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0152 1.13 M
Table 1: DMET genes with sex differences in human hepatic expression.