Table 2a

Tissue (µg eq/g) (n=3)	Oral (30 mg/kg)						Transdermal (~61.3 mg/kg³)
Tissue (µg eq/g) (n=3)	2h	8h	24h	72h	168h	360h	2h	8h	24h	72h	168h	360h
Blood/Plasma	0.75	1.23	0.63	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ
Adrenal Gland	7.32	6.96	4.98	0.26	LOQ	LOQ	LOQ	2.55	6.10	2.76	LOQ	LOQ
Eye	20.55	31.85	48.75	37.13	18.93	19.91	LOQ	1.70	37.77	47.54	13.69	28.29
Liver	9.80	10.07	8.27	0.30	LOQ	LOQ	LOQ	1.96	4.58	3.39	LOQ	LOQ
Pituitary	10.32	9.13	5.91	0.44	1.10	LOQ	LOQ	LOQ	6.98	LOQ	LOQ	LOQ
Skin-Pigmented	7.27	13.29	10.62	20.09	LOQ	LOQ	LOQ	LOQ	1.68	17.19	LOQ	LOQ
Skin-Unpigmented	2.15	2.14	1.31	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ
Thyroid /Parathyroid	8.32	12.68	2.93	0.96	0.31	LOQ	LOQ	1.86	3.32	1.42	1.54	LOQ
Bone	0.76	0.68	0.86	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	LOQ	2.10
Stomach	473.73	422.16	59.74	LOQ	LOQ	LOQ	LOQ	2.40	LOQ	48.18	4.16	LOQ
Small Intestine	378.90	46.60	322.26	0.76	LOQ	LOQ	LOQ	8.71	38.82	37.77	1.99	LOQ
Large Intestine	1.31	96.26	161.54	4.07	LOQ	LOQ	LOQ	1.94	42.51	21.06	LOQ	LOQ
Dose Site4	NA						LOQ	35.28	91.71	24.64	LOQ	LOQ
Stratum Corneum5	NA						NA	109.81	17.78	13.12	1.33	1.20

LOQ = below limit of quantitation
NA = not applicable to route of administration
3dose estimated based upon residual patch analysis
4 pigmented skin + unpigmented skin at the dose site
5 expressed as per cent of dose (mean dose of 61.3 mg/kg based upon residual patch analysis)

Table 2a: Mean Radioactivity in Blood, Plasma, Selected Tissues and Stratum Corneum (Transdermal only) from Long-Evans Rats Administered a Single Oral ¹⁴C-Donepezil or 24-h Transdermal Patch Containing ¹⁴C-Donepezil.