Period

Parameters

Control
X ± SD

4-CPA 10 ppm
X ± SD

4-CPA 20 ppm
X ± SD

SUBACUTE

 

 

AST (U/L)

118.1± 8.4

191.4 ± 5.6*

187.4 ± 15.6*

ALT (U/L)

46.1± 4.0

62.1 ± 4.2*

53.8± 4.0*

LDH (U/L)

595.4 ± 11.0

824.7 ± 24.4*

1012.2 ± 23.8*

TPRO (g/dL)

6.6 ± 0.6

7.1 ± 0.5

6.5 ± 0.4

TALB (mg/dL)

4.7 ± 0.4

4.2 ± 0.2

3.9 ± 0.3*

TKOL (mg/dL)

46.4 ± 4.6

48.5 ± 5.6

53.2 ± 5.0

TBİL (mg/dL)

0.06± 0.009

0.07 ± 0.011

0.08 ± 0.01*

 

 

 

 

 

SUBCHRONIC

 

 

AST (U/L)

106.0 ± 4.1

117.7 ± 3.9*

120.0 ± 5.1*

ALT (U/L)

42.4 ± 3.8

47.5 ± 3.4*

47.2 ± 2.1*

LDH (U/L)

650.5 ± 20.6

895.8 ± 28.6*

1026.8 ± 26.1*

TPRO (g/dL)

7.3 ± 0.3

7.0 ± 0.2

6.6 ± 0.1*

TALB (mg/dL)

4.3 ± 0.2

4.2 ± 0.3

3.8 ± 0.2*

TKOL (mg/dL)

48.2 ± 4.2

55.2 ± 8.0

50.8 ± 7.9

TBİL (mg/dL)

0.04 ± 0.009

0.06 ± 0.005*

0.07 ± 0.009*

Each value represents the Mean ± SD. * p<0.05
Table 2: Effects of 4-CPA 10-20 ppm on serum biomarker levels of rats at subacute and subchronic.