Data are mean ± SD. (n=4) * p<0.05, ** p<0.01 vs. pre-treatment. The individual values are representing as following symbols (○; No.1, □; No.2, Δ; No.3, ◊; No.4). AST; aspartate aminotransferase, ALT; alanine aminotransferase, γ--GTP; γ-glutamyltransferase, ALP; alkaline phosphatase.

Figure 1: Serum laboratory tests representing liver function after the administration of hemoglobin-vesicles at a dose of 1400 mg Hb/kg in cynomolgus monkeys.