Drug |
NSAIDs |
DMARDs |
Opioids |
Steroids |
Substrate |
Inhibitor |
Inducer |
Aspirine |
X |
|
|
|
2C8, 2C9 |
|
2C19 |
Diclofenac |
X |
|
|
|
2C8, 2C9, 2C19, 3A4, |
2C8, 2C9, 3A4 |
|
Ibuprofen |
X |
|
|
|
2C8, 2C9, 2C19 |
2C9 |
|
Indometacine |
X |
|
|
|
2C9, 2C19 |
2C9, 2C19 |
|
Ketoprofen |
X |
|
|
|
|
2C9, 2C10 |
|
Metamizol |
X |
|
|
|
|
|
2B6, 3A4 |
Naproxen |
X |
|
|
|
1A2, 2C8, 2C9 |
|
|
Oxaprozin |
X |
|
|
|
2C9 |
|
|
Paracetamol |
X |
|
|
|
1A1, 1A2, 2A6, 2C8, 2C9, 2D6, 2E1, 3A4 |
3A4 |
2D6, 2E1, 3A4/5 |
Phenylbutazon |
X |
|
|
|
2C9 |
|
3A4 |
Piroxicam |
X |
|
|
|
2C9 |
2C9 |
|
Betamethasone |
|
|
|
X |
19A |
3A4 |
19A |
Hydrocortisone |
|
|
|
X |
3A4 |
3A4 |
2C8, 3A4 |
Prednisone |
|
|
|
X |
3A4 |
3A4 |
1A1, 1A2, 3A4 |
Codeine |
|
|
X |
|
2D6, 3A4 |
2D6 |
|
Fentanyl |
|
|
X |
|
3A4 |
3A4 |
|
Morphin |
|
|
X |
|
2C8, 3A4 |
|
|
Tramadol |
|
|
X |
|
2B6, 2D6, 3A4 |
2D6, 3A4 |
|
Chloroquine |
|
X |
|
|
1A1, 2C8, 2D6, 3A4 |
2D6 |
|
Cyclosporine |
|
X |
|
|
3A4 |
2C19, 2D6, 3A4 |
|
Hydochloroquine |
|
X |
|
|
|
2D6 |
|
Leflunomide |
|
X |
|
|
2C8, 2C9 |
2C8, 2C9 |
|
Additional administration of antibiotics in the therapy of PD could influence the metabolism of the other drugs administered for RA therapy. Potent antibiotic agents against periodontal bacterial pathogens are listed in Table |