Table 1

	M1		M2		M3		M4
	V_m	K_m	V_m	K_m	V_m	K_m	V_m	K_m
MOUSE	0.34 ± 0.05	86.25 ± 34.0	0.28 ± 0.03	48.12 ± 18.1	0.52 ± 0.07	64.1 ± 27.7	0.59 ± 0.07	239.2 ± 55.1
Rat	0.04 ± 0.01	59.02 ± 16.5	0.03 ± 0.01	17.3 ± 8.6	0.33 ± 0.02	74.2 ± 8.1	0.19 ± 0.02	53.12 ± 14.2
Rabbit	0.14 ± 0.01	50.22 ± 10.2	0.16 ± 0.01	21.4 ± 3.3	0.50 ± 0.02	71.0 ± 5.3	0.59 ± 0.07	122.8 ± 39.1
Dog	0.31 ± 0.06	115.85 ± 38.8	0.39 ± 0.06	76.2 ± 32.0	1.20 ± 0.14	75.1 ± 32.0	0.12 ± 0.03	128.5 ± 68.5
Pig	1.02 ± 0.32	73.0 ± 21.1	0.56 ± 0.12	53.6 ± 19.7	0.57 ± 0.1	90.21 ± 22.6	0.65 ± 0.08	120.1 ± 35.5
Baboon	0.16 ± 0.03	59.2 ± 8.8	0.26 ± 0.04	37.78 ± 6.5	0.68 ± 0.1	80.5 ± 15.2	0.15 ± 0.01	162 ± 22.1
Human	0.36 ± 0.1	96.1 ± 10.1	0.26 ± 0.02	41.2 ± 7.1	1.51 ± 0.4	78.4 ± 14.1	0.62 ± 0.05	674 ± 73.15
Hepatocytes	0.39 ± 0.13	35.58 ± 40.1	0.97 ± 0.26	56.1 ± 38.7	1.7 ± 0.52	67.6 ± 49.4	ND	ND

V_m: μM/min/mg protein
K_m: μM
ND – Not Detectable

Table 1: Kinetic parameters for 17-OHPC hydroxylated metabolites (M1-M4) observed in Rabbit, Rat, Dog, Mouse, Pig, Baboon, Human Liver Microsomes and Human Hepatocytes. All the experiments were performed in triplicate and the values are reported as mean ± SD. The kinetic parameters were calculated by expressing metabolite levels in terms of 17-OHPC equivalents.