Figure 4: Classical apoptotic pathway. Several genes conventionally designated as apoptosis regulators are represented in this pathway. Nine of these genes were differentially expressed in CGNs: Casp3 (caspase 3), c-jun (jun proto-oncogene), Bcl2l1 (Bcl2-like 1), Hrk (Harakiri), Igf1r (insulin-like growth factor 1 receptor), Irf1 (interferon regulatory factor 1), Myc (myelocytomatosis oncogene), Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), Tnfrsf21 (tumor necrosis factor receptor superfamily, member 21).