Analyte Mean ± SD Median (Range-Max – Min  )

Diabetic CD1mice- Pre fasting

Diabetic CD1 mice- Post fasting

Diabetic db/db mice Pre fasting

Diabetic db/db mice Post fasting

Alkaline phosphatase (U/L) (ALP)

422.66 ± 45.40 411 (494-366)

104.33 ± 15.8* 101 (131-85)

265.11 ± 38.79 268 (342-228

89.85 ± 35.22* 100 (134-40)

Bilirubin (µmol/L) (T-BIL)

3.70 ± 1.99 3.42 (6.84-1.70)

13.39 ± 2.73* 13.68 (17.10-10.26)

6.15 ± 1.94 6.8 (8.55-3.42)

12.14 ± 1.41* 11.97 (12.65-11.62)

Aspartate aminotransferase (U/L)(AST)

191 ± 12.31 191 (220-158)

115 ± 35.82* 114 (180-81)

155 ± 41.45 146 (226-113)

130.8571 ± 8.83 132 (142-121)

Alanine aminotransferase (U/L)(ALT)

108 ± 19.30 103 (142-92)

56 ± 21.91* 51 (96-32)

87.66 ± 32.48 90.00 (140-48)

86.1429 ± 9.65 84.00 (100-71)

Triglyceride mmol/L (TGY)

4.21 ± 1.17 4.23 (5.62-2.50)

3.48 ± 0.47* 3.42 (4.27-2.97)

1.26 ± 0.59 1.03 (2.32-0.76)

1.89 ± 0.10* 1.94 (2.05-1.76)

Cholesterol mmol/L (CHO)

4.83 ± 0.21 4.75 (5.23-4.63)

3.54 ± 0.48* 3.39 (4.24-2.92)

3.01 ± 0.66 3.36 (3.72-2.07)

3.57 ± 1.52* 4.12 (4.71-3.21)

Serum Creatinine mmol/L

0.01 ± 0.03 0.17 (0.02-0.01)

0.02 ± 0.04* 0.02 (0.02-0.01)

0.02 ± 0.007 0.01 (0.03-0.01)

0.08 ± 0.02* 0.08 (0.10-0.03)

Urea nitrogen mmol/L(BUN)

19.63 ± 6.03 17.13 (28.56-13.56)

17.37 ± 3.53 18.74 (21.06-11.42)

17.25 ± 1.84 17.49 (19.90-14.90)

14.58 ± 7.32 13.2 (27.84-6.42)

Uric Acid mmol/L(U-ACID)

0.46 ± 0.14 0.44 (0.74-0.30)

0.39 ± 0.09 0.36 (0.55-0.32)

0.21 ± 0.02 0.21 (0.24-0.17)

0.35 ± 0.13* 0.35 (0.65-0.23)

Total Protein g/L (P)

58.32 ± 10.08 59.50 (64-50)

178.88 ± 36.59* 189.00 (214-121)

55.14 ± 5.21 54 (63-48)

123.33 ± 12.00* 122 (150-108)

Glucose mmol/L

38.09 ± 5.41 39.9 (43.92-30.80)

16.62 ± 3.65* 15.73 (23.57-13.06)

25.82 ± 4.76 25.11 (33.30-18.98)

13.41 ± 3.42* 13.07 (17.64-10.65)

Sodium mmol/(Na)

146.50 ± 6.34 145.50 (155-138)

304.5 ± 43.58* 321 (330-216)

155 ± 4.80 165 (172-141)

153.55 ± 3.04 147 (165-147)

Potassium mmol/L(K)

7.16 ± 1.72 7.00 (9-5)

9 ± 3.00 10.00 (12-4)

7.65 ± 2.10 8.20 (11.20-6.50)

8.0 ± 7.52 9.12 (15.20-6.50)

Calcium mmol/L(Ca)

2.73 ± 0.37 2.81 (3.1-2.2)

1.38 ± 0.80* 1.25 (2.65-0.65)

2.71 ± 0.46 2.75 (3.30-2.25)

2.55 ± 0.49 2.38 (3.30-2.10)

Table 2: Serum biochemistry values of STZ induced CD1 mice, and db/db mice (Pre and post fasting variables) Presented as mean ± standard deviation (n=7) with median and range. * p<0.05 compared with pre and post fasted mice using unpaired student t test.