| Topoisomerase I inhibitors (CPT-11, NB-506) |
Topoisomerase II inhibitors (ETP, DXR) |
| Other drugs (CDDP, VCR, 5-FU) |
MDR drugs (DXR, ETP, VCR) |
| Alkylating agents (CDDP, CPA) |
NB-506 |
| Topoisomerase II inhibitors-Non P-gPmdr (ETP) |
CDDP, Paclitaxel, MMC |
| CDDP |
Paclitaxel, DXR, VCR, CPT-11 |
| Paclitaxel |
VCR, CDDP |
Abbreviations: CPT-11, Irinotecan; NB-506, glucosyl derivative of indolocarbazole;
ETP, Etoposide; DXR, Doxorubicin; CDDP, Cisplatin; VCR, Vincristine;
5-FU, 5-fluorouracil; CPA, Cyclophosphamide ; MMC, Mitomycin C |
