CP min  (mg/ml) τ (h) Dose (mg/kg) Experimental calves Mean ± S.E.M.
C1 C2 C3 C4 C5 C6
1.0 8 D* 1.44 1.49 1.44 1.56 1.42 1.64 1.49 ± 0.035
D0 0.84 0.87 0.79 0.96 0.83 1.05 0.89 ± 0.039
12 D* 2.24 2.31 2.15 2.53 2.20 2.76 2.36 ± 0.095
D0 1.64 1.69 1.50 1.93 1.61 2.17 1.75 ± 0.10
2.0 8 D* 2.88 2.98 2.88 3.12 2.84 3.28 2.99 ± 0.070
D0 1.68 1.74 1.58 1.92 1.66 2.1 1.78 ± 0.079
12 D* 4.48 4.62 4.3 4.06 4.4 5.52 4.733 ± 0.19
D0 3.28 3.38 3.0 3.86 3.22 4.34 3.51 ± 0.20
Where,
D*=Priming or Loading dose,
D0=Maintenance dose
τ =Dosage interval,
CP min=Minimum therapeutic concentration in plasma
Table 2: Dosage regimens for combined administration of Amikacin (10 mg/kg) and W. somnifera (500 mg/kg) in healthy calves.