Figure 3: Photomicrograph of liver tissue from pyridostigmine bromide treated animals.
(A) vehicle control showing clear hepatic lobule, radial liver cell cord and clear hepatic sinusoid; (B) pyridostigmine 20 mg/kg dose treated animals showing cloudy swelling of some hepatocytes with focal inflammatory piecemeal necrosis; (C) pyridostigmine 30 mg/kg dose treated animals showing hepatocytes with multiple, prominent and enlarged nuclei started to appear and cytoplasmic acidophilic bodies and (D) pyridostigmine 45 mg/kg dose treated animals showing prominent acidophilic bodies in most hepatocytes with micro- and macro vesicular steatosis (10×).