(A) vehicle control animals and (B) pyridostigmine 20 mg/kg dose treated animals showing normal kidney architecture and histology; (C) pyridostigmine 30 mg/kg dose treated animals showing diffuse tubular injury with neutrophil polymorph infiltration, tubular dilatation, tubular atrophy, interstitial inflammatory cells infiltration and fibrosis and (D) pyridostigmine 45 mg/kg dose treated animals showing microcystic tubular dilatation, tubular casts and glomerulosclerosis. Thickening of basement membranes, dilated tubules, protein casts and interstitial inflammation was also found (10×).
