Attributes Pharmacopoeial reference Test method Specification
Pyridostigmine bromide tablet Potassium iodate tablet
Weight uniformity BP Vol. IV (Appendix XII C/A3 02, 2008) % error of each tablet from average weight <5% <5%
Dissolution time BP Vol. IV (Appendix XII B/A2 86-88, 2008) Basket type Dissolution test apparatus T80% 60 min t75% 15 min
Disintegration time BP Vol. IV (Appendix XII A/A2 83, 2008) Disintegration test apparatus ≥ 15 min ≥ 15 min
Hardness test BP Vol. IV (Appendix XVII H/A4 24, 2008) “Monsanto” Tablet hardness tester ≥ 70 N ≥ 70 N
Friability test BP Vol. IV (Appendix XVII G/A4 23, 2008) BP standard tablet friability tester ≤ 1% ≤ 1%
Moister content Not in Monograph (Musa et al., 2008) Water absorption ratio >10% >10%
Pyridostigmine Bromide Assay Waehler et al. 1993 [24]
BP Vol. II (Page no. 1785, 1980)
HPLC (% LC)
And Titrametry
95.0-105.0% 95.0-105.0%
Potassium Iodate Assay BP Vol. II (Page no. 1785, 2008) Titrametry 95.0-105.0% 95.0-105.0%
Table 1: Stability tests parameters and specifications for pyridostigmine bromide and potassium iodate tablet according to British Pharmacopoeia (BP).