Day Pyrido-stigmine (mg/kg, p.o) Hb (gm/dl) M ± SEM RBC (106/mm3) M ± SEM WBC (103/mm3) M ± SEM Differential leukocyte count in % (M ± SEM)
N L E B M
0 control 12.70 ± 1.50 4.78 ± 0.13 5.02 ± 0.87 38.25 ± 2.27 52.28 ± 1.94 1.77 ± 0.07 1.57 ± 0.11 6.13 ± 0.88
20 12.40 ± 1.84ns 4.91± 0.85ns 5.42 ± 0.23ns 40.45 ± 2.45ns 48.14 ± 1.62ns 1.25 ± 0.11ns 2.04 ± 0.01ns 8.12 ± 0.67ns
30 12.82 ± 1.36ns 5.75 ± 0.24ns 5.18 ± 0.45ns 44.09 ± 2.68ns 46.61 ± 1.69ns 2.40 ± 0.13* 1.18 ± 0.02ns 5.72 ± 0.93ns
45 13.15 ± 1.12ns 5.91 ± 0.42ns 5.09 ± 0.42ns 42.13 ± 3.67ns 46.70 ± 1.58ns 2.52 ± 0.22* 2.58 ± 0.58ns 6.07 ± 0.50ns
15 control 12.56 ± 1.97 5.11 ± 0.25 5.20 ± 0.79 40.22 ± 1.51 50.17 ± 1.60 1.98 ± 0.02 0.92 ± 0.14 6.71 ± 0.84
20 13.42 ± 1.23ns 5.78 ± 0.41ns 8.32 ± 0.35* 34.57 ± 2.30ns 52.70 ± 3.97ns 3.80 ± 0.27ns 1.09 ± 0.22ns 7.84 ± 0.97ns
30 11.08 ± 1.11ns 4.72 ± 0.21ns 8.97 ± 0.36* 32.43 ± 2.39ns 53.52 ± 2.11ns 7.51 ± 0.32*** 1.44 ± 0.33ns 5.10 ± 0.56ns
45 9.86 ± 1.14ns 3.71 ± 0.20** 9.34 ± 1.34** 34.45 ± 3.12ns 52.90 ± 4.22ns 8.00 ± 0.97*** 1.22 ± 0.11ns 3.43 ± 0.33*
30 control 12.80 ± 1.56 5.45 ± 0.56 5.35 ± 0.78 39.24 ± 2.67 48.57 ± 1.55 1.26 ± 0.09 1.13 ± 0.01 9.80 ± 0.39
20 11.50 ± 1.22ns 4.55 ± 0.43ns 8.95 ± 1.02ns 31.08 ± 2.97ns 52.93 ± 3.97ns 5.32 ± 0.81** 1.33 ± 0.03ns 9.34 ± 0.49ns
30 9.83 ± 1.27ns 4.10 ± 0.62ns 9.76 ± 1.21* 30.25 ± 2.17ns 53.07 ± 4.97ns 8.12 ± 0.94*** 1.05 ± 0.07ns 8.51 ± 0.94ns
45 9.02 ± 1.31ns 3.02 ± 0.55* 10.94 ± 1.46** 30.86 ± 4.07ns 52.48 ± 3.84ns 8.65 ± 1.05*** 1.30 ± 0.06ns 6.71 ± 0.82*
45 control 12.76 ± 1.23 5.29 ± 0.56 5.60 ± 0.41 37.62 ± 3.40 50.25 ± 1.90 2.14 ± 0.07 1.42 ± 0.03 8.93 ± 1.11
20 9.34 ± 1.36ns 3.83 ± 0.25ns 9.35 ± 1.33* 30.97 ± 2.67ns 51.50 ± 3.43ns 5.35 ± 0.97* 1.58 ± 0.02ns 10.60 ± 1.45ns
30 9.42 ± 1.99ns 3.38 ± 0.62ns 10.33 ± 1.17** 27.80 ± 2.53ns 52.28 ± 3.27ns 10.35 ± 1.09*** 1.45 ± 0.03*** 8.22 ± 1.06ns
45 8.09 ± 1.07* 3.04 ± 0.77* 10.90 ± 0.69** 27.03 ± 2.07* 54.44 ± 3.17ns 10.45 ± 1.22*** 1.04 ± 0.07*** 7.04 ± 1.02ns
n=10. *P<0.05, **P<0.01, ***P<0.001 and ns=not significant when compared to respective control group
Table 4: Effect of daily oral administration of Pyridostigmine Bromide tablet up to 45 days on peripheral blood parameters of rats.