Table 1

Species	Strain	n	ED200 ELGV, µg/kg (95% confidence interval)	Relative Potency
Guinea pig	Hartley	25	1.6 (1.0-2.3)	1
Hamster	Golden Syrian	25	2232.0 (769.0-3033.0)	1,395
Mouse	A/J	25	26.0 (16.6-41.2)	16
	BALB/c	48	359.0 (185.0-641.0)	224
	ICR	30	71.9 (29.8-155.0)	45
Rat	Brown-Norway	20	24.1 (17.0-32.0)	15
	Fischer 344	20	24.2 (12.1-38.6)	15
	Lewis	20	28.8 (22.6-35.6)	18
	Sprague-Dawley	20	17.2 (9.0-26.4)	11

Table 1: Table showing relative ED₂₀₀ ELGV of methacholine producing pulmonary gas trapping increases in the guinea pig, hamster, mouse, and rat (from Stengel et al. [23]). Estimated inhaled dose of methacholine was calculated based on nebulizer solution concentration, usable nebulizer output, inhalation time, chambre airflow, minute volume, and animal body weight.