Entry Solvent condition t Yielda(%)
1b CH2Cl2 Reflux 6h 39
2b THF Reflux 8h 51
3 Neat 60°C 4h 64
4 Neat 80°C 2h 72
5c Ultrasonication, neat 200W 40min 96
6c,d Ultrasonication, neat 200W 40min 25
aThe yields refer to the isolated pure products.
bThe reaction was carried out in 5 mL of solvent.
cThe reaction was irradiated by using ultrasonicator laboratory system.
dThe reaction was carried out in the absence of KHSO4-SiO2.
Table 4: Conversion of aldoximes into nitriles using KHSO4-SiO2 as a catalyst under different conditions.