Figure 5: IC50 plots depicting the effects of exemestane (Exe, squares) and 17-hydroexemestane (17-Hexe, diamonds) on the formation of estradiol from testosterone. Incubations were performed with cDNA-expressed CYP19 (aromatase) and 50 μM testosterone for 20 min at 37°C. Data represent means of duplicate determinations from a single experiment.