Figure 5: Plasma concentration of midazolam in mice (A), rats (B), dogs (C), monkeys (D), and microminipigs (E) after the single intravenous and oral administration of 5 P450 substrates such as caffeine, losartan, omeprazole, dextromethorphan, and midazolam. Each point and bar is represented as the mean ± S.D. of three animals.