Drug (dose)
Route
Rate constant (hour-1)
Half-life (hours)
Insulin (1IU/kg bw)
IP
0.3634
1.91
Glibenclamide (3mg/kg bw)
Oral
0.3132
2.21
Extract (mg/kg bw)
50
IP
0.2432
2.85
Oral
0.2328
2.98
100
IP
0.2215
3.12
Oral
0.2081
3.33
150
IP
0.2606
2.66
Oral
0.2335
2.92
Table 2:
Pharmacokinetics of the hypoglycemic activity for the first four hours of the three doses of the aqueous leaf extracts of C. pareira.
