Effect of oral and intraperitoneal administration

Treatment	Route	Glucose levels at varying times in mmole/dL
Treatment	Route	0hr	1hr	2hr	3hr	4hr	6hr	24hr
Control	Oral	5.30 ± 0.28	5.04 ± 0.17	5.02 ± 0.13	5.12 ± 0.23	5.08 ± 0.08	5.18 ± 0.25	4.96 ± 0.21
	IP	5.12 ± 0.18	5.28 ± 0.22	5.28 ± 0.13	5.12 ± 0.22	5.18 ± 0.08	5.22 ± 0.18	5.22 ± 0.29
Diabetic control	Oral	24.42 ± 3.18^A	25.48 ± 2.79^B	26.12 ± 2.35^B	26.84 ± 1.92^B	27.58 ± 1.45^B	28.88 ± 1.11^Ba	30.08 ± 1.49^Cb
	IP	19.84 ± 1.26^A	21.48 ± 1.41^B	23.08 ± 1.50^Ba	24.24 ± 1.71^Ba	25.20 ± 1.36^Ab	25.74 ± 1.60^Ab	28.04 ± 1.47^Cc
Diabetic/Glib	Oral	23.80 ± 2.72^Ac	20.82 ± 2.43^Ab	17.62 ± 3.15^Ab	12.62 ± 3.68^Aa	8.68 ± 2.00	5.74 ± 1.06	6.82 ± 1.01
Diabetic/Insulin	IP	20.88 ± 2.69^Bb	7.30 ± 0.54^a	6.32 ± 0.44	6.08 ± 0.41	5.46 ± 0.47	4.68 ± 0.38	6.98 ± 0.94^a
Extract dose (mg/kg body weight)
50	Oral	25.88 ± 1.12^Ac	15.86 ± 2.50^Ab	11.78 ± 5.33^a	8.02 ± 3.14	5.18 ± 1.62	4.68 ± 1.33	6.66 ± 1.09
50	IP	15.42 ± 3.05^Aa	7.78 ± 1.64	8.22 ± 2.07	6.00 ± 0.98	4.96 ± 1.47	6.02 ± 1.57	8.38 ± 1.54
100	Oral	22.60 ± 4.50^Ac	16.76 ± 0.69^Ab	14.10 ± 2.06^Ab	9.42 ± 0.89^a	5.58 ± 0.94	5.10 ± 1.18	7.58 ± 0.59
100	IP	16.66 ± 3.54^Aa	9.68 ± 4.66	8.58 ± 3.43	7.42 ± 2.73	6.06 ± 1.57	7.72 ± 3.06	10.46 ± 2.53^B
200	Oral	24.14 ± 4.12^Aa	17.18 ± 4.68^A	12.60 ± 5.07^A	11.48 ± 4.71^A	11.36 ± 4.72^A	8.90 ± 2.17^A	12.00 ± 3.32^B
200	IP	18.20 ± 1.27^Ac	13.42 ± 5.10^Ab	12.40 ± 4.43^Aa	8.78 ± 2.96^A	5.68 ± 0.71	7.12 ± 1.51	9.44 ± 2.44^A
300	Oral	20.88 ± 3.40^Ac	17.30 ± 1.58^Ab	14.02 ± 3.41^Aa	10.30 ± 3.87	8.10 ± 1.55	7.46 ± 2.86	11.32 ± 4.49^A
300	IP	15.62 ± 3.87^Aa	7.76 ± 2.42	7.10 ± 1.88	6.30 ± 1.19	5.50 ± 0.50	5.92 ± 0.71	7.48 ± 1.58

Values are expressed as Means ± SD for five animals per group. Means within respective columns followed by similar upper case letters are not significantly different at p ≤ 0.05 by ANOVA and post ANOVA; means within respective rows followed by similar lower case letters are not significantly different at p ≤ 0.05 by ANOVA and post ANOVA.

Table 1: Effect of oral and intraperitoneal administration of aqueous stem bark extracts Acacia nilotica on blood glucose levels in alloxan induced diabetic mice.