Disease Chronological behavior Drugs used Peptic ulcer Acid secretion high in noon and at night H2 blockers [51] Asthma Precipitation of attacks  during night or at early morning hours B2agonists,antihistamine [52-54] Cardiovascular disease BP is at its lowest during sleep cycle and rises in early morning Nitroglycerine,Calcium channel blockers,Ace inhibitors [55-58]. Arthritis Pain in the morning and more pain in the night NSAIDS,glucocorticoids[59,60] Diabetis mellitus Increase in blood sugar level after meal Sulfonyl urea,insulin,bioguanide[61]. Hypercholesterolemia Cholesterol  synthesis is generally high during night than day HMG COA reductase inhibitors [62].

Table 3: Diseases requiring pulsatile drug delivery systems.