Drug Metabolite  Biotransformation Therapeutic action Atomoxetine 4-Hydroxyatomoxetine         Aromatic hydroxylation Treatment of attention-deficit   hyperactivity disorder Atorvastatin 2- or 4-Hydroxyatorvastatin Anti-hypercholesterolemia Chlorpromazine 7-Hydroxychlorpromazine Anti-depressive Clomiphene 4-Hydroxyclomiphene Anti-uterotrophic Granisetron 7-Hydroxygranisetron Anti-nausea Indapamide 5-Hydroxyindapamide Anti-hypertensive Levamisole 4-Hydroxylevamisole Anthelmintic Propafenone 5-Hydroxypropafenone Anti-arrhythmic Propranolol 4-Hydroxypropranolol Anti-arrhythmic Alprazolam 4-Hydroxyalprazolam         Aliphatic hydroxylation Anti-depressant Bupropion Hydroxybupropion Anti-mental depression Clarithromycin 14-Hydroxyclarithromycin Anti-biotic Cyclosporin A Hydroxycyclosporin A Immunosuppressive Ibuprofen Hydroxyibuprofen Anti-inflammatory Itraconazole Hydroxyitraconazole Anti-mycotic Metronidazole Hydroxymetronidazole Anti-biotic Midazolam 1′-Hydroxymidazolam Anxiolytic eŠect Nebivolol 4- or 4′-Hydroxynebivolol Vasodilation Nefazodone Hydroxynefazodone Anti-depressant Praziquantel 4-Hydroxypraziquantel Anti-neurocysticercosis Quinidine 3-Hydroxyquinidine Anti-arrhythmic Risperidone 9-Hydroxyrisperidone Anti-psychotic Simavastatin Simavastatinhydroxylic acid Anti-hypercholesterolemia Amiodarone Desethylamiodarone         N-Dealkylation Anti-arrhythmic Azonafade N-Desmethylazonaˆde Anti-tumoral Chlordiazepoxide Desmethylchlordiazepoxide Anxiolytic Citalopram Desmethylcitalopram Anti-depressant Clobazam N-Desmethylclobazam Anti-epileptic Clomipramine N-Desmethylclomipramine Anti-depressant Clozapine Norclozapine Anti-psychotic Ferroquine N-Demethylferroquine Anti-malarial N,N-Didemethylferroquine Fluoxetine Nor‰uoxetine Anti-depressant Ivabradine N-Desmethylivabradine Bradycardia Lumefantrine Desbutyllumefantrine Anti-malarial Mianserin N-Desmethylmiaserin Anti-depressant Verapamil Norverapamil Anti-arrhythmic Oxybutynin N-Desethyloxybutynin Smooth muscle relaxant Rosuvastatin N-Desmethylrosuvastatin Anti-hypercholesterolemia Sertraline N-Desmethylsertraline Anti-depressant Sibutramine N-Desmethylsibutramine Treatment of obesity N,N-Didesmethylsibutramine Zolmitriptan N-Demethylzolmitriptan Treatment of migraine Zopiclone (S)-Desmethylzopiclone Treatment of insomnia Artemether Dihydroartemisinin     O-Dealkylation Anti-malarial Ivabradine O-Demethylivabradine Bradycardia Tramadol O-Demethyltramadol Centrally acting analgesic Venlafaxine O-Desmethylvenlafaxine Anti-depressant Acebutol Diacetolol N-Acetylation Anti-hypertensive Albendazole Albendazolesulfoxide Sulfoxidation Anti-parasitic Aripiprazole Dehydroaripiprazole Dehydrogenation Anti-psychotic Bupropion Threo/erythro-hydrobupropion Carbonyl reduction Anti-depressant Carbamazepine Carbamazepine-10,11 epoxide   Epoxidation Anti-epilepsy   Diacerein Rhein Deacetylation Treatment of osteoarthritis Isosorbide Dinitrate 5- or 2-Isosorbide mononitrate Denitration Treatment of angina pectoris  Losartan Carboxylosartan Carboxylation Anti-hypertensive Minoxidil Minoxidil sulfate Sulfation Stimulating hair growth Oxcarbazepine 10-Hydroxy-10,11-dihydrocarbamazepine Hydroxylation & Dehydrogenation Anti-epileptic Procainamide N-Acetyl procainamide N-Acetylation Anti-arrhythmic Rifampicin 25-Desacetylrifampicin Deacetylation Treatment of tuberculosis Thiocolchicoside 3-O-Glucuronidated-Thiocolchicoside Glucuronidation   Muscle relaxant Tramadol O-Demethyl-N demethyltramadol N,O-Dealkylation Centrally acting analgesic Triamterene Hydroxytriamterene sulfate Sulfation Diuretic

Table 1: Pharmacologically active metabolites of currently marketed drugs [2].