| Drugs |
Reactive intermediate |
Toxicity |
| Acetaminophen |
Quinine-imine |
Hepatotoxicity |
| Carbamazepine |
2-hydroxyl,quinine-imine |
Agranulocytosis, aplastic anemia |
| Clarithromycin |
Nitroalkane |
Hypersensitivity |
| Clozapine |
Desmethylclozapine |
Agranulocytosis |
| Dapsone |
Hydroxylamine, nitroso |
Hemolysis, Hypersensitivity |
| Diclofenac |
Acyl glucuronide, benzoquinone imine |
Hepatotoxicity |
| Halothane |
Trifluoroacetyl |
Hepatesis |
| Indomethacin |
Iminoquinone |
Hypersensitivity, Agranulocytosis, Hepatotoxicity |
| Isonizaid |
Isonicotinic acid, acetylating species |
Hypersensitivity |
| Phenacetin |
p-nitrosophenetole |
Hepatotoxicity |
| Procainamide |
Hydroxylamine, nitroso |
Agranulocytosis |
| Tacrine |
7-OH-tacrine |
Hepatotoxicity |
| Tamoxifene |
N-oxide, N-oxide-epoxide |
Carcinogenicity |
| Ticlodipine |
Keto, S-oxide |
Agranulocytosis, aplastic anemia |
| Tienilic acid |
Thiopene S-oxide |
Hypersensitivity, hepatitis |
| Troglitazone |
Conjugates, benzoquinone, quinine epoxide |
Hepatotoxicity |
| Valproic acid |
Acyl glucuronide, 2-N-propyl-4-pentenoic acid |
Hypersensitivity, Hepatotoxicity |
|
