Group Sleeping time (min) Mean ± SEM Percentage reduction Liver weight(gms) Mean ± sem Percentage reduction Vehicle control 47.17 ± 0.94 -- 2.5 ± 0.22 -- Diseased control 144.8 ± 1.22 -- 4.6 ± 0.33 -- Standard 57.33 ± 1.45*** 60.4 2.6 ± 0.21** 43.4 TLF 100 131.2 ± 2.35 9.3 3.8 ± 0.30* 17.3 BAF 100 78.67 ± 2.01** 45.6 3.1 ± 0.16** 32.6 BTF 100 94.50 ± 1.66* 34.7 3.3 ± 0.21** 28.2

Table 3: Effect of fractions of GGME 100 mg/kg on Pentobarbitone induced sleeping time in Paracetamol induced toxicity in mice and liver weight in rats. Values are mean ± SEM (n=6) one way ANOVA. Where, * represents significant at p<0.05, ** represents highly significant at p<0.01, and *** represents very significant at p<0.001. All values are compared with toxicant. (Toluene Fraction-TLF, 2-Butanone Fraction (BTF) and n-Butanol Fraction (BAF