MHC-I Allele RANK POS. N SEQUENCE C MW (Da) SCORE % OPT. 8mer_H2_Db 1 147 SIL GGINFMTT VKN 821.93 13.596 25.90% 8mer_H2_Db 2 109 VDS SCGTSWTI YPP 812.92 10.984 20.92% 8mer_H2_Db 3 67 GGF GNWMVPLM LGA 906.15 10.568 20.13% 8mer_H2_Db 4 29 RAE LCKPGFFF GSG 940.18 10.043 19.13% 8mer_H2_Db 5 16 WSG MVGAGLSI LIR 728.9 8.059 15.35% 9mer_H2_Db 1 147 SIL GGINFMTTV KNM 921.06 16.377 32.52% 9mer_H2_Db 2 146 SSI LGGINFMTT VKN 935.09 14.44 28.67% 9mer_H2_Db 3 66 IGG FGNWMVPLM LGA 1053.33 14.031 27.86% 9mer_H2_Db 4 124 STS GHPGNSVDL AIF 876.92 12.987 25.79% 9mer_H2_Db 5 39 FGS GQLYNAVIT SHA 960.09 11.476 22.79% 10mer_H2_Db 1 76 LML GAPDMSFPRL NNV 1072.26 10.794 18.34% 10mer_H2_Db 2 146 SSI LGGINFMTTV KNM 1034.22 9.981 16.96% 10mer_H2_Db 3 153 NFM TTVKNMRSAS ISL 1076.22 9.867 16.76% 10mer_H2_Db 4 39 FGS GQLYNAVITS HAI 1047.17 7.555 12.84% 10mer_H2_Db 5 166 ISL EHLSLFVWTV FVT 1189.41 7.286 12.38% 11mer_H2_Db 1 146 SSI LGGINFMTTVK NMR 1162.39 20.946 26.35% 11mer_H2_Db 2 43 QLY NAVITSHAIMM IFF 1169.41 12.764 16.06% 11mer_H2_Db 3 139 SLH CSGVSSILGGI NFM 974.14 12.41 15.61% 11mer_H2_Db 4 160 NMR SASISLEHLSL FVW 1138.3 9.483 11.93% 11mer_H2_Db 5 31 ELC KPGFFFGSGQL YNA 1166.35 7.18 9.03%

Table 2: Promiscuous MHC ligands, having C-terminal ends are proteosomal cleavage sites of Dracunculus medinensis . (All rows highlighted in red represent predicted binders and A peptide highlighted in violet has a C-teminus predicted by the cleavage model used).