Enzyme
BAT
NAB
% Metabolized in 120 min
Human CYP-expressing microsomes
1A1
18
62
1A2
8.4
8
1B1
32
17
2E1
<3
7
Others
<3
<1
Rat CYP-expressing microsomes
1A1
34
33
1A2
31
27
Others
<3
<1
Induced rat microsomes*
Untreated
22
12
DEX (3A)
23
12
3MC (1A)
70
79
PB (3A, 2B)
59
10
Table 2:
Metabolism of BAT and NAB by Microsomal Preparations. *Liver Microsomes from rats pretreated with dexamethasone (DEX), 3-methlycholanthrene (3-MC) or phenobarbital (PB), showing the primary CYPs induced by these treatments.
