Parameters
Healthy group
Nephropathy group
α(/hr)
2.31 ± 0.62
3.01* ± 0.78
t
1/2
α (hr)
0.30 ± 0.10
0.23* ± 0.04
β (/hr)
0.87 ± 0.18
0.58** ± 0.26
t
1/2
β (hr)
0.80 ± 0.21
1.20* ± 0.19
AUC (µg hr /mL)
28.42 ± 4.76
86.04** ± 8.94
MRT (hr)
1.48 ± 0.31
0.97* ± 0.06
K
21
(/hr)
1.27 ± 0.23
1.38* ± 0.18
K
12
(/hr)
0.33 ± 0.09
0.95** ± 0.19
K
el
(/hr)
1.58 ± 0.52
1.27* ± 0.30
Vd
area
(L/kg)
0.31 ± 0.01
0.19* ± 0.07
Cl
B
(ml/h/kg)
22.76 ± 3.41
36.38* ± 7.28
Table 1:
Kinetic parameter of amoxicillin in healthy and nephropathic goats after single dose intravenous administration at 10 mg/kg body weight (n=6, ± SEM).**p<0.01, *p<0.05 versus healthy group.
