Subject Age (months) Sex Race Duration (months) Lead Level* EPP* Iron* CYP2D6 genotype CYP2D6 AS** M01 16 M C 44 17 13 52 *2×2*2 3 M03 84 F AA 39 26 126 29 *1*9 1.5 M06 16 F AA 14 22 38 88 *1*2 2 M08 21 M H 11 17 38 81 *1*4×2 1 M09 27 M C 18 26 68 150 *1*5 1 M12 48 F AA 28 17 18 114 *1*29 1.5 M13 15 M C 28 32 138 49 *1*2 2 M15 48 F H 15 27 40 78 *2*41 1.5 M21 17 M AA 9 16 38 78 *1*41 1.5 M24 18 M C 11 22 5 113 *2*45 or46 1.5 M28 48 M AA 8 21 39 114 *1*5 1

Table 1: Demographics of subjects who completed study. *Blood concentrations noted at time of enrollment. Mean lead level 22.1 ± 5.2 mcg/dl. Mean EPP 51 ± 43.5 mcg/dl. Mean iron level 86 ± 35 mcg/dl. EPP indicates erythrocyte protoporphyrin; CYP2D6, Cytochromes P450 2D6; C: Caucasian; AA: African American; H: Hispanic; AS: activity score. **AS is a value is assigned to each allele according to its activity. The sum of values for both alleles is the AS. The value of the AS has a predictive phenotype. (AS 0=Poor metabolizer, AS 0.5=Intermediate metabolizer, AS 1-2=Extensive metabolizer, and AS >2=Ultra metabolizer).