Enzyme Role Nitration1 HNE-Modification2 Carbonylation3 Up-Regulated4 Down-Regulated4 Decreased Activity5 FBA Glycolysis MCI, EAD LAD EAD PCAD, LAD     TPI Glycolysis EAD, LAD EAD         GAPDH Glycolysis LAD   PCAD       PGK Glycolysis   MCI         PGM Glycolysis EAD   EAD       Enolase Glycolysis MCI, EAD, LAD MCI, EAD, LAD LAD LAD   EAD PK Glycolysis     PCAD     MCI LDH LAF LAD MCI       MCI Aconitase TCA Cycle   LAD   PCAD   LAD MDH TCA Cycle MCI EAD         COX ETC         PCAD   ATPase ETC EAD, LAD MCI, EAD, LAD PCAD   LAD MCI, EAD, LAD GDH Metabolism/ Excitotoxicity EAD         EAD CK Metabolism     LAD     LAD Cu/Zn SOD Antioxidant     PCAD PCAD   EAD* MnSOD Antioxidant   EAD, LAD   LAD   EAD* GST Antioxidant MCI LAD   LAD   LAD CR Antioxidant   MCI         Prx2 Antioxidant EAD           Prx6 Antioxidant MCI LAD         MRP Antioxidant MCI LAD

Table 1: Oxidized proteins related to metabolism and antioxidant capacity of the cell are summarized.1 see [19,23-25]. 2 see [19,21,22,47]. 3 see[18,41,43,105,106]. 4 see [21,47,107]. 5 see [19-22,47,105]. (HNE = 4-hydroxynonenal; FBA = fructose bisphosphate aldolase; TPI = triose phosphate isomerase; GAPDH = glyceraldehyde- 3-phosphate dehydrogenase; PGK = phosphoglycerate kinase; PGM = phosphoglycerate mutase; PK = pyruvate kinase; LDH = lactate dehydrogenase; MDH = malate dehydrogenase; COX = cytochrome C oxidase; ATPase = ATP synthase; GDH = glutamate dehydrogenase; CK = creatine kinase; SOD = superoxide dismutase; GST = glutathione-S-transferase; CR = carbonyl reductase; Prx = peroxiredoxin; MRP = multi-drug resistant protein; LAF = lactic acid fermentation; TCA = tricarboxylic acid; ETC = electron transport chain). *Overall SOD activity is reduced in EAD.