Enzyme Role Nitration1 HNE-Modification2 Carbonylation3 Up-Regulated4 Down-Regulated4 Decreased Activity5
FBA Glycolysis MCI, EAD LAD EAD PCAD, LAD    
TPI Glycolysis EAD, LAD EAD        
GAPDH Glycolysis LAD   PCAD      
PGK Glycolysis   MCI        
PGM Glycolysis EAD   EAD      
Enolase Glycolysis MCI, EAD, LAD MCI, EAD, LAD LAD LAD   EAD
PK Glycolysis     PCAD     MCI
LDH LAF LAD MCI       MCI
Aconitase TCA Cycle   LAD   PCAD   LAD
MDH TCA Cycle MCI EAD        
COX ETC         PCAD  
ATPase ETC EAD, LAD MCI, EAD, LAD PCAD   LAD MCI, EAD, LAD
GDH Metabolism/ Excitotoxicity EAD         EAD
CK Metabolism     LAD     LAD
Cu/Zn SOD Antioxidant     PCAD PCAD   EAD*
MnSOD Antioxidant   EAD, LAD   LAD   EAD*
GST Antioxidant MCI LAD   LAD   LAD
CR Antioxidant   MCI        
Prx2 Antioxidant EAD          
Prx6 Antioxidant MCI LAD        
MRP Antioxidant MCI LAD        
Table 1: Oxidized proteins related to metabolism and antioxidant capacity of the cell are summarized.1 see [19,23-25]. 2 see [19,21,22,47]. 3 see[18,41,43,105,106]. 4 see [21,47,107]. 5 see [19-22,47,105]. (HNE = 4-hydroxynonenal; FBA = fructose bisphosphate aldolase; TPI = triose phosphate isomerase; GAPDH = glyceraldehyde- 3-phosphate dehydrogenase; PGK = phosphoglycerate kinase; PGM = phosphoglycerate mutase; PK = pyruvate kinase; LDH = lactate dehydrogenase; MDH = malate dehydrogenase; COX = cytochrome C oxidase; ATPase = ATP synthase; GDH = glutamate dehydrogenase; CK = creatine kinase; SOD = superoxide dismutase; GST = glutathione-S-transferase; CR = carbonyl reductase; Prx = peroxiredoxin; MRP = multi-drug resistant protein; LAF = lactic acid fermentation; TCA = tricarboxylic acid; ETC = electron transport chain).
*Overall SOD activity is reduced in EAD.