|
Overall Survival |
Progression-Free-Survival |
Variables |
HR 95%CI P-value |
HR 95%CI P-value |
Age > 60 years |
1.111 1.024-1.428 <0.008 |
|
Extra nodal sites-R > 1 |
1.090 0.918-1.285 0.8 |
1.235 0.809-1.168 0.4 |
LDH |
1.000 0.999-1.007 0.7 |
1.050 1.000-1.232 0.07 |
LDH-R |
1.523 1.001-1.812 <0.05 |
1.204 0.838-1.408 0.7 |
IPI ≥ 2 |
1.039 0.962-1.935 0.8 |
1.035 0.965-1.672 0.4 |
IPI-R > 2 |
1.178 0.849-1.308 0.6 |
1.354 0.738-1.944 0.2 |
CR prior to transplant |
0.679 0.472-1.001 0.1 |
0.656 0.572-1.001 0.07 |
ALC-15 ≥ 500 cells/µl |
0.424 0.236-0.617 <0.0004 |
0.608 0.466-0.804 <0.02 |
AMC-15 ≥ 600 cell/µl |
2.177 1.459-2.861 <0.002 |
1.525 1.000-1.904 0.06 |
ALC/AMC-15 ratio ≥ 1 |
0.220 0.089-0.540 <0.0001 |
0.171 0.115-0.349 <0.0001 |
ANC-15 |
0.915 0.904-1.003 0.2 |
0.916 0.812-1.021 0.1 |
Plts-15 |
0.999 0.994-1.004 0.7 |
0.999 0.994-1.003 0.7 |
PS-R > 1 |
1.043 0.589-1.958 0.9 |
1.011 0.988-1.168 0.9 |
Stage-R III/IV |
1.597 1.086-1.918 <0.04 |
1.449 0.999-1.973 0.07 |
Pre-transplant Rituximab |
0.522 0.409-0.906 <0.01 |
0.845 0.582-1.190 0.5 |
Abbreviations: Age-R = age at relapse; Extranodal sites-R = extranodal sites at relapse; LDH = lactate dehydrogenase; LDH-R = lactate dehydrogenase at relapse; PS
= performance status; PS-R = performance status at relapse; stage-r = stage at relapse; IPI = International Prognostic Index; IPI-R = International Prognostic Index at
relapse; CR = complete remission; PR = partial response; ALC = absolute lymphocyte count; ANC-15 = absolute neutrophil count at day 15; AMC = absolute monocyte
count; and plts-15 = platelets at day 15 |