Key cluster

EASE-score

Sub-cluster

P-value (Benjamini)

Transcription binding

5.7

Transcription factor binding

4.4E-6

 

 

Transcription cofactor activity

7.5E-4

Apoptosis

4.86

Regulation of apoptosis

1.7E-5

 

 

Cell development

1.6E-2

 

 

Cell differentiation

3.3E-1*

Cellular stress

4.00

Response to stress

3.1E-6

 

 

Response to wounding

3.6E-3

 

 

Response to external stimulus

5.9E-2

 

 

Defense response

2.0E-1

 

 

Inflammatory response

4.5E-1

Cell cycle

3.8

Regulation of cell cycle

3.7E-3 

Intracellular transport

3.76

Golgi vesicle transport

2.5E-4

 

 

ER to Golgi vesicle-mediated transport

1.1E-2

Biotic stimulus

2.57

Response to biotic stimulus

3.8E-2

Tissue healing

2.08

Wound healing

9.1E-2

 

 

Hemostasis

1.2E-1

 

 

Blood coagulation

1.7E-1

 

 

Regulation of body fluid levels

3.5E-1

 

 

Platelet activation

4.9E-1

 

 

Complement and coagulation cascades

8.8E-1


* correlated to “cell development” (?=0.87)
Table 3: Key- and sub-clusters of genes associated to the ongoing posttraumatic inflammation or bone regeneration. The genes are differentially expressed at day 1 and day 7 in patients with hip fractures.