Key cluster EASE-score Sub-cluster P-value (Benjamini)
Transcription binding 5.7 Transcription factor binding 4.4E-6
    Transcription cofactor activity 7.5E-4
Apoptosis 4.86 Regulation of apoptosis 1.7E-5
    Cell development 1.6E-2
    Cell differentiation 3.3E-1*
Cellular stress 4.00 Response to stress 3.1E-6
    Response to wounding 3.6E-3
    Response to external stimulus 5.9E-2
    Defense response 2.0E-1
    Inflammatory response 4.5E-1
Cell cycle 3.8 Regulation of cell cycle 3.7E-3 
Intracellular transport 3.76 Golgi vesicle transport 2.5E-4
    ER to Golgi vesicle-mediated transport 1.1E-2
Biotic stimulus 2.57 Response to biotic stimulus 3.8E-2
Tissue healing 2.08 Wound healing 9.1E-2
    Hemostasis 1.2E-1
    Blood coagulation 1.7E-1
    Regulation of body fluid levels 3.5E-1
    Platelet activation 4.9E-1
    Complement and coagulation cascades 8.8E-1
*correlated to “cell development” (κ=0.87)
Table 3: Key- and sub-clusters of genes associated to the ongoing posttraumatic inflammation or bone regeneration. The genes are differentially expressed at day 1 and day 7 in patients with hip fractures.