Figure 2: Genome-scale miRNA profiling of hESC cardiac and neural specification by small molecule induction.
(A) Hierarchal clustering of differentially expressed miRNAs in undifferentiated hESCs (hESC), cardiac-induced hESCs by NAM (cardiac), and neural-induced hESCs by RA (neural). Statistically significant p values and clustering analysis were provided by LC Sciences as part of miRNA microarray service.
(B) Pie charts showing decreased contributions of a set of pluripotence-associated miRNAs (purple) and increased contributions of distinct sets of cardiac- (green) and neural- (blue) driving miRNAs to the entire miRNA populations upon cardiac and neural induction of pluripotent hESCs by small molecules.