Subcutaneous implantation of plain BAG or β-TCP granules failed to induce
osteoblastic activity and calcification, but seeding of both biomaterials with
hASCs and/or supplementation with BMP-2 induced osteoblastic activity.
However, calcification was only observed, when BMP-2 activated hASCs were
seeded on BAG or hASCs were seeded on β-TCP.
G1 – G4 = groups 1 – 4; OBPCs = osteoblastic precursor cells; d = statistical
difference between groups 2 and 3; e = statistical difference between groups
2 and 4; f = statistical difference between groups 1 and 4; N.D. = not detected
(score = 0); single asterisks indicates statistical differences between weeks
4 and 8; arrows with asterisks indicates statistical differences between BAG
and β-TCP.