PARAMETER Control (se) Treated (se) P-value Cortisol (µg/dl) 0.34 (0.36) 1.75 (0.36) 0.049 Insulin (mU/l) -0.2 (4.90) -3.65 (4.90) 0.645 Glucose (mg/dl) 3.5 (1.33) -2.5 (1.33) 0.033 Basophils (cells/µl) -5.92 (12.73) -4.92 (12.73) 0.9584 Eosinophils (cells/µl) -3.75 (25.08) -49 (25.08) 0.2711 Neutrophils (cells/µl) -226.92 (142.65) 446.5 (142.65) 0.0042 Lymphocytes (cells/µl) -162.33 (132.09) -51.00 (132.09) 0.5833 Monocytes (cells/µl) -3.58 (30.14) 45.25 (30.14) 0.3159

Table 1: Different baseline adjusted hematological parameter estimates in the control and treated group. As there was no interaction between time and treatment for the hematological parameters reported in this table, the reported values correspond to the difference between the average over the different timepoints (T1, T2, T3, T4 and the baseline (T0), with corresponding P-value for the null hypothesis that this difference is the same in the treated and control group.