Figure 1: The concept of anchoring of the human, induced, pluripotent stem cells (hiPSCs) to the cardiac sarcomeres (A: A-band; Z: Z-line) with the aid of the heterospecific, tetravalent antibodies (htAbs) is presented at this figure. Icons for some of the elements are explained on the left side of this diagram. The htAbs are first spiked into the solution flowing over the sarcomeres (a). The htAbs anchor onto the sarcomeres by the myosin (A-band), α-actinin (Z-line), actin, titin binding domains of the htAbs (only the combination of anti-myosin and anti-α-actinin is shown for clarity here) (b). After clearing out the unbound htAbs, the solution is spiked with the hiPSCs (c). The hiPSCs, with the cell surface display of SSEA-4, SSEA-3, TRA-1-81, and TRA-1-60 (only the combination of the SSEA-4 and TRA-1-60 is shown for the clarity here) dock into the binding domains of the htAbs anchored onto the sarcomeres (d).