Figure 1: (A) The leukaemic stem cell (LSC) model proposes that leukaemic blasts originate from a common primitive progenitor that has the capacity to self-renew. (B) Conventional therapy for leukaemia has been designed to eliminate leukaemic blasts. These therapies may not effectively eradicate the LSC population which have the functional characteristics of self-renewal, differentiation and proliferation, which ultimately recapitulates the disease [67].