| Source/species |
Differentiation protocol |
Hepatocyte specific markers/functions |
Reference |
| r-MSC |
FGF-4+HGF+ITS+Dexa |
AFP, HNF3, HNF1,CK18,ALB |
[35] |
| r-MSC |
MSC+HGF+CNP |
AFP, CK18,CK19 |
[36] |
| r-MSC |
HGF+EGF+ Dexa |
ck19, AFP, DPP
IViNOS |
[32] |
| h-MSC |
MACS sorted CD105 + ATMSCs/ HGF+FGF1+
FGF4 /OSM+Dexa |
ALB, AFP, TTR, HNF-4,TDO2, CK18, TTR, ammonia detoxification, PAS staining,
LDL-uptake |
[34] |
| h-MSC |
HGF+bFGF+ nicotinamide + OSM + Dexa |
CK-18, CK-19, ALB,TTR, CYP2E1, EBPβ |
[16] |
| h-MSC |
EGF+FGF2 / HGF + FGF2 + nicotinamide / OSM + Dexa |
AFP,ALB, CK18, TAT,TDO2, G6P, HNF-4, urea synthesis, CYP activity.
LDL-uptake, PASstaining |
[37] |
| h-MSC |
HGF+OSM+Dexa+ nicotinamide |
AFP, CK18,ALB, TDO2,TAT,AAT, HNF-4, urea synthesis, PAS staining, CYP
activity |
[38] |
| h-MSC |
OSM+TSA+DMSO |
CK18, α-FP,α-SMA |
[39] |
|
