Figure 2:Contrast between speed lesion evolution of the skin and underlying tissues in minipig. A, B, C. Evolution of skin injury after irradiation. After irradiation a latency period is observed on cutaneous tissue and an edema appears on day 70 post irradiation (B). This injury leads to dry and then wet desquamation (C) before necrosis. D, E, F. Evolution of underlying tissues after irradiation: histological analysis with hematoxilin-eosin staining. A disorganization of underlying structures appears previously at the 10th week (E), leading to necrosis (F).