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Figure 4: Schedule of the reference cell therapy treatment for cutaneous radiation syndrome. First, physical dosimetry realized as soon as possible after irradiation provides information about irradiated area extent and allows an exhaustive excision surgery. Secondly, 3 to 4 weeks after surgery a first autologous skin graft is achieved. Thirdly the schedule of each following stages (such as number of BM-MSC injections) are realized depending on the absorbed dose, clinical evolution and therapeutic delay. BM-MSC are harvested during the first surgical act, expanded and four quality controls are performed before injections. This figure has been realized through clinical report cases [14,15,50,51]. |