Authors iPSC Source Vector Genes Host Transplantation Organ Transplantation Timeline Teratomas Nelson et al. [11] mice lentivirus OKSM mice intramyocardial 8 weeks NO Kawai et al. [12] mice retrovirus OKSM mice striatum and cortex 2,4 weeks YES Yamashita et al. [13] mice retrovirus OKSM mice striatum and cortex 2 weeks YES OKSM 4 weeks YES mice adenovirus OKSM mice striatum and cortex 4 weeks YES Yang et al. [7] mice retrovirus OKSM mice IV 13 weeks NO Zhang et al. [14] rat lentivirus OKSM rat intramyocardial 2, 4, 6 weeks NO in 80.6% Fink et al. [15] rat adenovirus OKSM rat striatum 13 weeks NO DurruthyDurruthy et al. [16] human lentivirus OKSM mice seminiferous tubules 8 weeks YES human lentivirus mRNA OKSM-V mice seminiferous tubules 8 weeks NO

Table 1: Outcomes on the tumor formation after transplantation of undifferentiated iPSc.