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Table 1: Comprehensive outlook of different clinical transplantation scenarios. Characteristics of allogeneic incompatibilities for various donor: recipient constellations in a HSCT situation. In a clinical transplantation setting where related/ unrelated donors are considered for transplantation, HLA alleles remain either identical/ different while the mHAGs are always different among the donor: recipient pair and its effects must be taken into account. The HLAdifferential and mHAG-identical situation does not occur, and therefore in a natural setting, it is not possible to determine the HLA mismatch effects exclusively. The lower line emphasizes the characteristics of the artificial allogeneic system, where the magnitude of HLA mismatch effects can be determined independent of mHAG effects. |