Figure 1: Schematic diagram of genomic editing for avian species with TALENs or CRISPR-Cas9. After genetic modification and gene knockout in cultured PGCs using TALENs or CRISPR-Cas9, the donor PGCs are transplanted into the blood vessel of recipient embryos. Germline chimeras can produce the knockout mutant offspring derived from the transplanted donor PGCs. White leghorn (WL) has a dominant pigmentation inhibitor and Korean Oge chicken (KOC) has a recessive pigmentation inhibitor. The white hybrid chicks from the donor WL PGCs can be distinguished from KOC progenies only by the feather color.