Figure 8: Histological sections of busulphan treated mouse testes after two months of inter-tubular mesenchymal cells transplantation. Similar two kinds of tubules as observed after Sertoli cell transplantation (Figure 7) are observed after transplantation of Mesenchymal cells(A). Interestingly both the interstitial compartment comprising Leydig cells and Sertoli cells in both the small ‘neo-formed tubules’ and bigger ‘native tubules’ were much more prominent. Mesenchymal cells apparently differentiated into Sertoli-like cells comprising the ‘neo-formed tubules’. The neo-formed and old tubules were observed in close proximity of each other (B). The sperm production was much more and spermatogenesis was much more organized (C-F) compared to after Sertoli cell transplantation (Figure 6 G). This suggests that already ‘committed’ Sertoli cells have less plasticity compared to Mesenchymal cells to differentiate into tubules which also are a better source of growth factors and cytokines that not only reverts spermatogenesis and sperm production, but also stimulates the somatic compartment comprising Leydig and Sertoli cells. Bar=20μm.