| Pluripotency stringency criteria |
| Mouse model systems |
** In vitro morphology and gene expression |
| ** In vitro teratoma formation |
| ** In utero chimeric embryogenesis |
| ** Tetraploid aggregation and germline transmission |
| Human model systems |
** In vitro morphology and gene expression |
| ** In vitro teratoma formation |
| Identification properties of iPSCs |
| Cellular biological properties |
Morphology, Growth, Telomere activity, Stem cell markers, Stem cell genes |
| Pluripotency |
Neural differentiation, Cardiac differentiation, Teratoma formation, Embryoid body, Chemeric mice, Tetraploid complementation |
| Epigenetic programming |
Promoter demethylation, DNA methylation globally, Histone demethylation |
