1.Disease modeling |
2. Regenerative medicine: tissue engineering and organ repair |
3. Drug screening for toxicity, drug development and drug discovery |
4. Genetic therapy; treatment of intractable and genetic disorders: |
** Sickle cell anemia |
** Cystic fibrosis |
** β- Thalassemia |
** Lysch - Nyhan syndrome |
** Hemophilia |
** Hurler syndrome |
** Fanconi anemia |
** Pompe disease |
** Dyskeratosiscongenita |
** Wilson disease |
** Schwachman-Bodian-Diamond syndrome |
** Down's syndrome |
** Primary myelofibrosis |
** Huntington's disease |
** Polycythemia rubravera |
** Parkinson's disease |
** Epidemolysisbulosae |
** Alzheimer's disease |
** Retinitis pigmentosa |
** Schizophrenia |
** Spinal muscular atrophy |
** Ducchene muscular dystropy |
|
** Amyotrophic lateral sclerosis |
5. Cell-based therapies. |
6. Synthesis of blood components: the following blood components haveĀ been generated from embryonic and iPSCs: |
[a] Red blood cells [definitive and primitive erythroid cells]; can be used in severe anemia or blood loss. |
[b] Megakaryocytes and platelets; transfusion in critical thrombocytopenia |
[c] Dendritic cells: antigen-specific vaccines for cancer or human immunodeficiency virus (HIV) |
[d] Natural killer cells: natural or antibody-assisted anticancer cytotoxicity |
[e] T- lymphocytes: antigen-specific anti-cancer or anti- HIV adoptive cell transfer. |
[f] B- lymphocytes |
[g] Neutrophils |
[h] Monocytes and macrophages |