MRI/Histologic pattern Neurospheres Adherent cells CE tumor ++ + NE tumor + + Tumor with necrosis – – High infiltration +/– ++ Mild infiltration +/– ++ Edema with or without infiltration – –

MRI: magnetic resonance imaging; CE: contrast enhancing; NE: non-contrast enhancing. Note: For neurospheres, the scale refers to their number, size and growth rate. For adherent cells, the scale refers as follows: +, temporary monolayer; ++, stabilized monolayer.

Table 1: Development of neurospheres and adherent cells with respect to MRI and the different pathologic features.