Histology MRI LOH9p,10q,17p 1p/19qCo-Del EGFRAmpl PTEN, TP53, TERTMut MGMTMeth Enhancing tumor CE + + ++ ++ + Tumor infiltration with MVP CE/NE + + + + + Tumor infiltration CE/NE +/– – + – – Edema with or without infiltration NE – – – – –

MRI: magnetic resonance imaging; MVP: microvascular proliferation; CE: contrast enhancing; NE: non-contrast enhancing; LOH: loss of heterozygosity: EGFR: epidermal growth factor receptor; PTEN: phosphatase and tensin homologue; TP53: tumor protein p53; TERT, telomerase reverse transcriptase; MGMT: O6- methylguanine-DNA methylatransferase. Note: LOH: The scale corresponds to the occurrence (+) or absence (–) of LOH on the tested regions; EGFR: The scale corresponds to the number of samples with gene amplification (++, 100%; +, <50%; –, no amplification); PTEN, TP53, TERT: The scale corresponds to the number of samples with gene mutations (–, wild type); MGMT: The scale corresponds to the number of samples with (+) or without (–) promoter methylation.

Table 2: Comparison among histologic patterns, MRI and molecular genetics.