LBH589 increases the mRNA levels

(A) RT-PCR of p21^Waf/Cip1 mRNA in N-GMSCs and H-GMSCs.
(B) Expression of the gene encoding p21^Waf/Cip1 was lower in H-GMSCs than in N-GMSCs (n=5, P<0.01; Student’s t test).
(C) Addition of TSA or LBH589 stimulated H-GMSCs for 48 h.
(D) p21^Waf/Cip1 mRNA levels were up-regulated in H-GMSCs after exposure to TSA or LBH589 (n=5, P<0.01; one-way analysis of variance).

Figure 7: Exposure to TSA or LBH589 increases the mRNA levels of p21Waf/Cip1 in IGF cells.